Matrine inhibits the adhesion and migration of BCG823 gastric cancer cells by affecting the structure and function of the vasodilator-stimulated phosphoprotein (VASP)
J Zhang, K Su, W Shi, Y Wang, P Hu, Y Wang… - Acta Pharmacologica …, 2013 - nature.com
Aim: Vasodilator-stimulated phosphoprotein (VASP) expression is upregulated in human
cancers and correlates with more invasive advanced tumor stages. The aim of this study was
to elucidate the mechanisms by which matrine, an alkaloid derived from Sophora species
plants, acted on the VASP protein in human gastric cancer cells in vitro. Methods: VASP was
expressed and purified. Intrinsic fluorescence spectroscopy was used to study the binding of
matrine to VASP. CD spectroscopy was used to examine the changes in the VASP protein …
cancers and correlates with more invasive advanced tumor stages. The aim of this study was
to elucidate the mechanisms by which matrine, an alkaloid derived from Sophora species
plants, acted on the VASP protein in human gastric cancer cells in vitro. Methods: VASP was
expressed and purified. Intrinsic fluorescence spectroscopy was used to study the binding of
matrine to VASP. CD spectroscopy was used to examine the changes in the VASP protein …
Matrine inhibits the adhesion and migration of BCG823 gastric cancer cells by affecting the structure and function of the vasodilator-stimulated phosphoprotein (VASP) …
ZJW Zhang JingWei, SK Su Ke, SWT Shi WenTao… - 2013 - cabidigitallibrary.org
Aim: Vasodilator-stimulated phosphoprotein (VASP) expression is upregulated in human
cancers and correlates with more invasive advanced tumor stages. The aim of this study was
to elucidate the mechanisms by which matrine, an alkaloid derived from Sophora species
plants, acted on the VASP protein in human gastric cancer cells in vitro. Methods: VASP was
expressed and purified. Intrinsic fluorescence spectroscopy was used to study the binding of
matrine to VASP. CD spectroscopy was used to examine the changes in the VASP protein …
cancers and correlates with more invasive advanced tumor stages. The aim of this study was
to elucidate the mechanisms by which matrine, an alkaloid derived from Sophora species
plants, acted on the VASP protein in human gastric cancer cells in vitro. Methods: VASP was
expressed and purified. Intrinsic fluorescence spectroscopy was used to study the binding of
matrine to VASP. CD spectroscopy was used to examine the changes in the VASP protein …
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