Maximum intravenous alteplase dose for obese stroke patients is not associated with greater likelihood of worse outcomes
Background IV alteplase is a primary treatment for acute ischemic stroke (AIS) at a weight-
based dose (WBD) of 0.9 mg/kg and maximum dose (MD) of 90 mg. There are conflicting
data regarding outcomes for those weighing≥ 100 kg. There is also a paucity of data in
Hispanics. The prevalence of adult obesity in the US has progressively increased; hence,
the percentage of patients receiving the maximum dose also is expected to rise. We
examined differences between patients treated with WBD vs. MD. Methods A retrospective …
based dose (WBD) of 0.9 mg/kg and maximum dose (MD) of 90 mg. There are conflicting
data regarding outcomes for those weighing≥ 100 kg. There is also a paucity of data in
Hispanics. The prevalence of adult obesity in the US has progressively increased; hence,
the percentage of patients receiving the maximum dose also is expected to rise. We
examined differences between patients treated with WBD vs. MD. Methods A retrospective …
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