… This review surveys the mechanical force-triggered DDS, mainly classified as direct
interaction forces, including compressive, tensile, and shear forces as well as induced forces …

… This mechanical microenvironment also provides shelter for … Blood vessels possess inherent
sensitivity to mechanical … phenotypic characteristics and mechanical signaling pathways of …

… 1 Schematic diagram of a drug delivery system triggered by different mechanical forces. (A
and B) Drug release in response to endogenous mechanical force. Reproduced with …

… Up to now, intravenous injection and oral drug delivery are still the main administration …
Most of the mechanical force-triggered TDDS developed for clinical application and pre-clinical …

… , and duration of drug release. Moreover, it enables precise drug delivery to targeted locations
… This review presents an overview of the progress in research on drug release systems …

… mechanical signals represents an important step towards the clinic application of
external mechanical force triggered drug delivery for complicated diseases. The proof-of-concept …

… Mechanoresponsive devices and materials that can trigger drug release using mechanical
… Shear force-triggered systems for targeted delivery and anti-thrombus therapy. a) Schematic …

… Physical deformation of drug carriers supported on an elastomer … mechanical force-triggered
release. Mooney group designed a compression-responsive system for controlled release …

… , a rapid drug release event was followed automatically. Force-triggered targeted cancer …
that can be used for highly specific drug delivery, which may potentially lead to smart cancer …

… of mechanical force-triggered drug loading of the delivery system. Specifically, mechanical
… incorporate CD as the drug carrier to prolong the drug release. The results showed that …