Mechanism of human group V phospholipase A2 (PLA2)-induced leukotriene biosynthesis in human neutrophils: a potential role of heparan sulfate binding in PLA2 …
Human group V phospholipase A 2 (hVPLA 2) has been shown to have high activity to elicit
leukotriene production in human neutrophils (Han, SK, Kim, KP, Koduri, R., Bittova, L.,
Munoz, NM, Leff, AR, Wilton, DC, Gelb, MH, and Cho, W.(1999) J. Biol. Chem. 274, 11881–
11888). To determine the mechanism by which hVPLA 2 interacts with cell membranes to
induce leukotriene formation, we mutated surface cationic residues and a catalytic residue of
hVPLA 2 and measured the interactions of mutants with model membranes, immobilized …
leukotriene production in human neutrophils (Han, SK, Kim, KP, Koduri, R., Bittova, L.,
Munoz, NM, Leff, AR, Wilton, DC, Gelb, MH, and Cho, W.(1999) J. Biol. Chem. 274, 11881–
11888). To determine the mechanism by which hVPLA 2 interacts with cell membranes to
induce leukotriene formation, we mutated surface cationic residues and a catalytic residue of
hVPLA 2 and measured the interactions of mutants with model membranes, immobilized …
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