difficulties during treatment. Many factors contribute to the increased stiffness of tumours;
from increased matrix deposition, matrix remodelling by forces from cancer cells and stromal
fibroblasts, matrix crosslinking, increased cellularity, and the build-up of both solid and
interstitial pressure. Increased stiffness then feeds back to increase tumour invasiveness
and reduce therapy efficacy. Increased understanding of this interplay is offering new …