Mechanisms governing protective pregnancy-induced adaptations of the pelvic floor muscles in the rat preclinical model
MM Rieger, M Wong, LA Burnett, FB Sesillo… - American journal of …, 2022 - Elsevier
Background The intrinsic properties of pelvic soft tissues in women who do and do not
sustain birth injuries are likely divergent. However, little is known about this. Rat pelvic floor
muscles undergo protective pregnancy-induced structural adaptations-sarcomerogenesis
and increase in intramuscular collagen content-that protect against birth injury. Objective We
aimed to test the following hypotheses:(1) the increased mechanical load of a gravid uterus
drives antepartum adaptations;(2) load-induced changes are sufficient to protect pelvic …
sustain birth injuries are likely divergent. However, little is known about this. Rat pelvic floor
muscles undergo protective pregnancy-induced structural adaptations-sarcomerogenesis
and increase in intramuscular collagen content-that protect against birth injury. Objective We
aimed to test the following hypotheses:(1) the increased mechanical load of a gravid uterus
drives antepartum adaptations;(2) load-induced changes are sufficient to protect pelvic …
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