Mechanistic insights into the C 55-P targeting lipopeptide antibiotics revealed by structure–activity studies and high-resolution crystal structures
The continued rise of antibiotic resistance is a global concern that threatens to undermine
many aspects of modern medical practice. Key to addressing this threat is the discovery and
development of new antibiotics that operate by unexploited modes of action. The so-called
calcium-dependent lipopeptide antibiotics (CDAs) are an important emerging class of
natural products that provides a source of new antibiotic agents rich in structural and
mechanistic diversity. Notable in this regard is the subset of CDAs comprising the …
many aspects of modern medical practice. Key to addressing this threat is the discovery and
development of new antibiotics that operate by unexploited modes of action. The so-called
calcium-dependent lipopeptide antibiotics (CDAs) are an important emerging class of
natural products that provides a source of new antibiotic agents rich in structural and
mechanistic diversity. Notable in this regard is the subset of CDAs comprising the …
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