[HTML][HTML] Melanocortin-3 receptors in the limbic system mediate feeding-related motivational responses during weight loss
M Mavrikaki, C Girardet, A Kern, AF Brantley… - Molecular …, 2016 - Elsevier
Objective Appetitive responses to weight loss are mediated by a nutrient-sensing neural
network comprised of melanocortin neurons. The role of neural melanocortin-3 receptors
(MC3R) in mediating these responses is enigmatic. Mc3r knockout mice exhibit a
paradoxical phenotype of obesity and reduced feeding-related behaviors in situations of
nutrient scarcity. Here we examined whether MC3Rs expressed in mesolimbic neurons
regulate feeding-related motivational responses. Methods Interactions between Mc3r …
network comprised of melanocortin neurons. The role of neural melanocortin-3 receptors
(MC3R) in mediating these responses is enigmatic. Mc3r knockout mice exhibit a
paradoxical phenotype of obesity and reduced feeding-related behaviors in situations of
nutrient scarcity. Here we examined whether MC3Rs expressed in mesolimbic neurons
regulate feeding-related motivational responses. Methods Interactions between Mc3r …
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