Melatonin ameliorates diabetes-induced brain injury in rats
ME Amer, AI Othamn, MA El-Missiry - Acta Histochemica, 2021 - Elsevier
Diabetic brain is a serious complication of diabetes, and it is associated with oxidative stress
and neuronal injury. This study investigated the protective effect of melatonin (MLT) on
diabetes-induced brain injury. A rat model of type 2 diabetes mellitus was produced by
intraperitoneal injection of nicotinamide 100 mg/kg, followed by intraperitoneal injection of
streptozotocin 55 mg/kg. The diabetic rats were orally administered MLT 10 mg/kg of body
weight for 15 days. MLT remarkably downregulated serum glucose levels. It also improved …
and neuronal injury. This study investigated the protective effect of melatonin (MLT) on
diabetes-induced brain injury. A rat model of type 2 diabetes mellitus was produced by
intraperitoneal injection of nicotinamide 100 mg/kg, followed by intraperitoneal injection of
streptozotocin 55 mg/kg. The diabetic rats were orally administered MLT 10 mg/kg of body
weight for 15 days. MLT remarkably downregulated serum glucose levels. It also improved …
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