Membrane transporters: Fundamentals, function and their role in ADME
J Keogh, B Hagenbuch, C Rynn, B Stieger, G Nicholls - 2016 - books.rsc.org
J Keogh, B Hagenbuch, C Rynn, B Stieger, G Nicholls
2016•books.rsc.orgIn the middle of the 20th century, the absorption, distribution, metabolism and elimination
(ADME) of pharmaceutical drugs was considered to be mediated primarily by simple
diffusion and metabolism. The concept that membrane transporter proteins existed and
could facilitate the flux of molecules across eukaryotic cell membranes was still in its infancy,
but as knowledge and information expanded, it was recognised that transporter proteins
could play an important role both in the movement of endogenous
(ADME) of pharmaceutical drugs was considered to be mediated primarily by simple
diffusion and metabolism. The concept that membrane transporter proteins existed and
could facilitate the flux of molecules across eukaryotic cell membranes was still in its infancy,
but as knowledge and information expanded, it was recognised that transporter proteins
could play an important role both in the movement of endogenous
In the middle of the 20th century, the absorption, distribution, metabolism and elimination (ADME) of pharmaceutical drugs was considered to be mediated primarily by simple diffusion and metabolism. The concept that membrane transporter proteins existed and could facilitate the flux of molecules across eukaryotic cell membranes was still in its infancy, but as knowledge and information expanded, it was recognised that transporter proteins could play an important role both in the movement of endogenous
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