Metachromins X and Y from a marine sponge Spongia sp. and their effects on cell cycle progression
Y Hitora, K Takada, Y Ise, SP Woo, S Inoue… - Bioorganic & Medicinal …, 2020 - Elsevier
Bioorganic & Medicinal Chemistry, 2020•Elsevier
New sesquiterpene quinones, metachromins X (1) and Y (2), together with the known
metachromins C (3), J (4), and T (5), were isolated as inhibitors of cell cycle progression in
the HeLa/Fucci2 cells. The structure of 1 was assigned by spectroscopic data and confirmed
by a total synthesis. The planar structure of 2 was determined by interpretation of
spectroscopic data, whereas its absolute configuration was analyzed by a combination of
chiral HPLC and CD spectroscopy. Metachromins X (1) and C (3) arrested the cell cycle …
metachromins C (3), J (4), and T (5), were isolated as inhibitors of cell cycle progression in
the HeLa/Fucci2 cells. The structure of 1 was assigned by spectroscopic data and confirmed
by a total synthesis. The planar structure of 2 was determined by interpretation of
spectroscopic data, whereas its absolute configuration was analyzed by a combination of
chiral HPLC and CD spectroscopy. Metachromins X (1) and C (3) arrested the cell cycle …
Abstract
New sesquiterpene quinones, metachromins X (1) and Y (2), together with the known metachromins C (3), J (4), and T (5), were isolated as inhibitors of cell cycle progression in the HeLa/Fucci2 cells. The structure of 1 was assigned by spectroscopic data and confirmed by a total synthesis. The planar structure of 2 was determined by interpretation of spectroscopic data, whereas its absolute configuration was analyzed by a combination of chiral HPLC and CD spectroscopy. Metachromins X (1) and C (3) arrested the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase.
Elsevier
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