The use of self-assembly strategies allows the synthesis of complex metallosupramolecular structures. The field is highly diverse but underlying principles can be applied to the design of synthetic strategies. In this chapter we illustrate that through use of coordination chemistry it is possible to synthesize different types of large assembly, including coordination cages and porphyrin assemblies, which exhibit interesting host-guest properties. We also illustrate the use of coordination chemistry to enable the synthesis of knotted structures, amongst the most intricate of known molecular structures.