Method and apparatus for the automated delivery of continuous neural stem cell trails into the spinal cord of small and large animals
AB Kutikov, SW Moore, RT Layer, PE Podell… - …, 2019 - journals.lww.com
Background Immature neurons can extend processes after transplantation in adult animals.
Neuronal relays can form between injected neural stem cells (NSCs) and surviving neurons,
possibly improving recovery after spinal cord injury (SCI). Cell delivery methods of single or
multiple bolus injections of concentrated cell suspensions thus far tested in preclinical and
clinical experiments are suboptimal for new tract formation. Nonuniform injectate dispersal is
often seen due to gravitational cell settling and clumping. Multiple injections have additive …
Neuronal relays can form between injected neural stem cells (NSCs) and surviving neurons,
possibly improving recovery after spinal cord injury (SCI). Cell delivery methods of single or
multiple bolus injections of concentrated cell suspensions thus far tested in preclinical and
clinical experiments are suboptimal for new tract formation. Nonuniform injectate dispersal is
often seen due to gravitational cell settling and clumping. Multiple injections have additive …
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