… (BCS) is an effective treatment for early-stage cancers as long as the margins of the
resected tissue are free of disease according to consensus guidelines for patient management. …

… between tumor tissue and normal tissue during surgery. Currently, tumor margins are
typically … Image-guided surgery using optical techniques requires an efficient combination of …

… same core method of determining tissue electrical … determine whether tissue is healthy or
malignant, whereas ClearEdge users first scan the probe over a patient’s normal breast tissue …

… spectrometry imaging and point-based tissue probing methods. For each modality, we
identify … of detecting any potential positive margins during surgery to avoid leaving any cancer …

… chemistry-based method has the potential to become a new highly selective margin management
method for live tissues… -sense method could be used to diagnose cancer tissues during …

… tumor margin assessment and review optical techniques … the excised tissue is evaluated
to determine if the margin is … , such that the overall surgical margin status as determined by …

… MS technique for chemical imaging and diagnosis of tissue … is directed toward a tissue sample,
allowing chemicals to be dissolved … The chemistry of the desorption process is similar to a …

… is a widely used technique for assessing margins, in which multiple frozen sections on
the margins of the excised tissue are usually performed. During this technique the excised …

… a powerful approach for tissue imaging and diagnosis [10–13]… MS technique for chemical
imaging and diagnosis of tissue … is directed toward a tissue sample, allowing chemicals to be …

… surgeon to determine the resection margin to avoid the unnecessary removal of normal tissue…
implementation of techniques of intraoperative pathology-assisted surgery (IPAS)—that is, …