… of active immunotherapy of malignancies, our interest has been the use of tumor-sensitized …
method. Based on the numbers of T cells recovered after 5 days of culture, LN cells depleted …

… been postulated to be a malignant proliferation of Treg cells … We speculate that transient
depletion of T cells in cancer … in the Figure 2 legend and Methods section. The absolute …

… + T cells did not predict survival in renal cell carcinoma [22]. Several studies, particularly in
hematologic malignancies… term than Treg depletion, encompassing the many means by which …

… as well as the enhancement of graft-versus-malignancy … T cells that recognize oligopeptides
in association with foreign HLA molecules. T-cell depletion (TCD) is an efficient means for …

… malignancies. Using HLA-A2–PR1 tetramer analysis, we found that the frequency of … (SMPT)
linker according to published methods. Clinical grade immunotoxin was made available to …

… -A-specific T cells were successfully expanded by this method (data not … T cells [10–13], to
tryptophan depletion via indoleamine-2,3-dioxygenase (IDO) [14, 15], to arginine depletion via …

… for treatment of hematologic malignancies. Twenty patients … a 2- to 3-log depletion of T
cells in most patients. Initial engraftment … of donor marrow as a method for preventing graft-versus-…

… to progression of various malignancies, including prostate cancer… Therefore, depleting Tregs
or suppressing their functions … indirect method through secretory factors or direct method via …

… CD4 + T cells played a critical role in retarding tumor growth. In addition, treatment with
anti-CD25 Ab to deplete CD4 + CD25 + regulatory T cells … that depletion of regulatory T cells is an …

… T cells frustrate productive tumor immune surveillance and represent an obstacle for cancer
immunotherapy. In mice, anti-CD25 antibody is an effective method of depleting … depletion of …