Methylated PP2A stabilizes Gcn4 to enable a methionine-induced anabolic program
AS Walvekar, G Kadamur, S Sreedharan… - Journal of Biological …, 2020 - ASBMB
Methionine, through S-adenosylmethionine, activates a multifaceted growth program in
which ribosome biogenesis, carbon metabolism, and amino acid and nucleotide
biosynthesis are induced. This growth program requires the activity of the Gcn4 transcription
factor (called ATF4 in mammals), which facilitates the supply of metabolic precursors that are
essential for anabolism. However, how Gcn4 itself is regulated in the presence of
methionine is unknown. Here, we discover that Gcn4 protein levels are increased by …
which ribosome biogenesis, carbon metabolism, and amino acid and nucleotide
biosynthesis are induced. This growth program requires the activity of the Gcn4 transcription
factor (called ATF4 in mammals), which facilitates the supply of metabolic precursors that are
essential for anabolism. However, how Gcn4 itself is regulated in the presence of
methionine is unknown. Here, we discover that Gcn4 protein levels are increased by …
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