Methylene blue reduces lung fluid filtration during the early phase of endotoxemia in awake sheep

OV Evgenov, G Sager, LJ Bjertnaes - Critical care medicine, 2001 - journals.lww.com
… The present study reveals that in sheep, MB attenuates pulmonary hypertension and
reduces the increment in lung fluid filtration during the early phase of endotoxemia.
Additionally, MB ameliorates systemic hemodynamics and prevents plasma and … In
summary, in ovine endotoxemia, MB markedly attenuates the early phase increase in
pulmonary capillary pressure and permeability, hence reducing lung fluid filtration. MB also
improves central hemodynamics and prevents plasma and lung lymph cGMP from rising. …
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