MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells
The transforming growth factor β (TGFβ) pathway plays critical roles during cancer cell
epithelial-mesenchymal transition (EMT) and metastasis. SMAD7 is both a transcriptional
target and a negative regulator of TGFβ signalling, thus mediating a negative feedback loop
that may potentially restrain TGFβ responses of cancer cells. Here, however, we show that
TGFβ treatment induces SMAD7 transcription but not its protein level in a panel of cancer
cells. Mechanistic studies reveal that TGFβ activates the expression of microRNA-182 (miR …
epithelial-mesenchymal transition (EMT) and metastasis. SMAD7 is both a transcriptional
target and a negative regulator of TGFβ signalling, thus mediating a negative feedback loop
that may potentially restrain TGFβ responses of cancer cells. Here, however, we show that
TGFβ treatment induces SMAD7 transcription but not its protein level in a panel of cancer
cells. Mechanistic studies reveal that TGFβ activates the expression of microRNA-182 (miR …
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