… hypothesized that miR-34a would be upregulated by seizures and contribute to seizure-induced
neuronal death. Our results show that seizures strongly upregulate miR-34a, and that …

… upregulated miRNA-34a might contribute to precipitating injury-induced neuronal apoptosis,
… Moreover, we found obvious neuronal apoptosis in the Mg 2+ -free-treated neurons, which …

… Particularly, microRNA has been found linked to seizure-induced neuronal death. In this …
[23] found that upregulation of microRNA-34a and neuronal death co-existed and correlated …

… an up-regulation of miR-34a in the post-status epilepticus rat hippocampus but also detected
a neuro-protective effect of targeting miR-34a during seizure-induced neuronal death. The …

… of p53 induction, as evidenced by downregulation of both Tp53 mRNA and protein levels in
… with neuronal injury and cell death. Massive neuronal demise occurs during traumatic brain …

… to an increase in cell apoptosis. These changes contribute to … Additionally, miR-34a has
been found to upregulate gene … levels during seizure-induced neuronal death or apoptosis [24]…

… was up-regulated in the course of seizureinduced neuronal apoptosis [26]. This evidence …
Taki, W.; Henshall, DC MicroRNA-34a upregulation during seizure-induced neuronal death. …

… Increasing evidence has shown that epileptogenesis results in eventual neuronal death
or … , suggesting an important role in neonatal seizure-induced excitotoxicity. Both miRNA-34a …

… It has been shown that miR-34a expression increases with age thereby promoting apoptosis
(Smith-Vikos and Slack, 2012), conversely our results suggest regulation changes during …

… , and then neuronal injury, neuronal apoptosis, PSD 95 and apoptosis-related protein …
In conclusion, the downregulation of miR-34a by DEX can play a protective role in propofol-…