Microarray-based genomic surveying of gene polymorphisms in Chlamydia trachomatis
BW Brunelle, TL Nicholson, RS Stephens - Genome Biology, 2004 - Springer
BW Brunelle, TL Nicholson, RS Stephens
Genome Biology, 2004•SpringerBy comparing two fully sequenced genomes of Chlamydia trachomatis using competitive
hybridization on DNA microarrays, a logarithmic correlation was demonstrated between the
signal ratio of the arrays and the 75-99% range of nucleotide identities of the genes.
Variable genes within 14 uncharacterized strains of C. trachomatis were identified by array
analysis and verified by DNA sequencing. These genes may be crucial for understanding
chlamydial virulence and pathogenesis.
hybridization on DNA microarrays, a logarithmic correlation was demonstrated between the
signal ratio of the arrays and the 75-99% range of nucleotide identities of the genes.
Variable genes within 14 uncharacterized strains of C. trachomatis were identified by array
analysis and verified by DNA sequencing. These genes may be crucial for understanding
chlamydial virulence and pathogenesis.
Abstract
By comparing two fully sequenced genomes of Chlamydia trachomatis using competitive hybridization on DNA microarrays, a logarithmic correlation was demonstrated between the signal ratio of the arrays and the 75-99% range of nucleotide identities of the genes. Variable genes within 14 uncharacterized strains of C. trachomatis were identified by array analysis and verified by DNA sequencing. These genes may be crucial for understanding chlamydial virulence and pathogenesis.
Springer
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