Intrusion-bordering migmatites comprise a substantial, high-grade metamorphic part of the Alvand aureole near Hamadan, western Iran. Abundant Al-rich metasedimentary rocks and various granites occur in this region. Migmatites consist of Bt + Sill + Grt + Crd + Sp ± Opx melanosomes and Grt + Pl + Kfs + Qtz leucosomes. These assemblages reflect upper pyroxene hornfels to lower sanidinite facies physical conditions. The appearance of orthopyroxene in these rocks marks the pressure–temperature transition from the pyroxene hornfels to the sanidinite facies. Field relations, mineral parageneses, and pressure–temperature estimates suggest that intrusion of granitic magma and concomitant partial melting of metasedimentary wallrock units were the main processes involved in the migmatization. Peak metamorphism took place at 650–750°C and ∼2–4 kbar; such high-temperature/low-pressure metamorphism was caused mainly by advective heat derived from the emplacement of plutons. Regional metamorphism, granitic magmatism, and contact metamorphism reflected arc construction and collision during subduction of a Neotethyan seaway and subsequent Late Cretaceous–early Tertiary oblique collision of Afro-Arabia (Gondwana) with the Iranian microcontinent.