… to the appearance of protons in the extra-mitochondrial medium [1], but it was … mitochondrion
by the respiratory chain. Early mitochondrial studies focused on isolated mitochondrial Ca 2…

… Mitochondrial Ca signaling contributes to the regulation of cellular energy metabolism, and
mitochondria … their ability to store Ca, shape the cytosolic Ca signals and generate ATP …

… velocity of mitochondrial Ca 2+ uptake and resting mitochondrial Ca 2+ concentration ([Ca
2+ ] … The concept of MICU1/MICU2 acting as gatekeepers for mitochondrial Ca 2+ uptake is in …

… pathological Ca 2+ signals from the ER to mitochondria. … Ca 2+ release and Ca 2+ uptake
mechanisms. We also explore the tight interplay between ER- and mitochondria-mediated Ca 2…

… two pathways under conditions of Ca 2+ activation. We show that αKG becomes limiting
when Ca 2+ enters in brain or heart mitochondria, but not liver mitochondria, resulting in a drop …

… Calcium signal propagation to the mitochondria results in stimulation of ATP production through
activation of the Ca … change the specificity of mitochondrial calcium signaling. In addition, …

… Here, we will focus on the roles of mitochondria-mediated Ca 2+ signaling in the
development of nerves and heart, especially pertaining to the new findings in the latter process. …

… to differentiate between effects on Ca 2+ signals due to altered mitochondrial Ca 2+ uptake
or impaired mitochondrial ATP production. Indeed, even though mitochondria in sea urchin …

… The aim of this review is to highlight recent findings in Ca 2+ signaling and to discuss their …
mitochondrial hydrogen exchange. Mitochondrial Ca 2+ uniporters have lower affinities for Ca …

… the mitochondrial Ca 2+ uptake in a variety of models. Perhaps it is inevitable that many
questions remain about the comparative cell physiology of mitochondrial Ca … of [Ca 2+ ] c signals …