Mitochondrial Ca2+ uptake with and without the formation of high-Ca2+ microdomains
The mitochondrial Ca2+ uniporter has low affinity for Ca2+, therefore it has been assumed
that submicromolar Ca2+ signals cannot induce mitochondrial Ca2+ uptake. The close
apposition of the plasma membrane or the endoplamic reticulum (ER) to the mitochondria
and the limited Ca2+ diffusion in the cytoplasm result in the formation of perimitochondrial
high-Ca2+ microdomains (HCMDs) capable of activating mitochondrial Ca2+ uptake. The
possibility of mitochondrial Ca2+ uptake at low submicromolar [Ca2+] c has not yet been …
that submicromolar Ca2+ signals cannot induce mitochondrial Ca2+ uptake. The close
apposition of the plasma membrane or the endoplamic reticulum (ER) to the mitochondria
and the limited Ca2+ diffusion in the cytoplasm result in the formation of perimitochondrial
high-Ca2+ microdomains (HCMDs) capable of activating mitochondrial Ca2+ uptake. The
possibility of mitochondrial Ca2+ uptake at low submicromolar [Ca2+] c has not yet been …
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