Mitochondrial Respiratory Chain and NAD (P) H Oxidase Are Targets for theAntiproliferative Effect of Carbon Monoxide in Human Airway SmoothMuscle
Carbon monoxide (CO), one of the end products of heme oxygenase activity, inhibits smooth
muscle proliferation by decreasing ERK1/2 phosphorylation andcyclin D1 expression, a
signaling pathway that is known to be modulated byreactive oxygen species (ROS) in airway
smooth muscle cells (ASMCs). Twoimportant sources of ROS involved in cell signaling are
the membrane NAD (P) Hoxidase and the mitochondrial respiratory chain. Thus, that CO
could modulateredox signaling in ASMCs by interacting with the heme moiety of NAD (P) …
muscle proliferation by decreasing ERK1/2 phosphorylation andcyclin D1 expression, a
signaling pathway that is known to be modulated byreactive oxygen species (ROS) in airway
smooth muscle cells (ASMCs). Twoimportant sources of ROS involved in cell signaling are
the membrane NAD (P) Hoxidase and the mitochondrial respiratory chain. Thus, that CO
could modulateredox signaling in ASMCs by interacting with the heme moiety of NAD (P) …
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