Mitogen-activated protein kinase pathways in osteoblasts
MB Greenblatt, JH Shim… - Annual review of cell and …, 2013 - annualreviews.org
Mitogen-activated protein kinases (MAPKs) are ancient signal transducers well
characterized as mediators of inflammation and neoplastic transformation. Recent work has
expanded our understanding of their developmental functions, particularly in the regulation
of bone mass via control of osteoblast differentiation. Here, we review the functions of MAPK
pathways in osteoblasts, including a consideration of MAPK substrates. In particular, MAPKs
function to regulate the key transcriptional mediators of osteoblast differentiation, with ERK …
characterized as mediators of inflammation and neoplastic transformation. Recent work has
expanded our understanding of their developmental functions, particularly in the regulation
of bone mass via control of osteoblast differentiation. Here, we review the functions of MAPK
pathways in osteoblasts, including a consideration of MAPK substrates. In particular, MAPKs
function to regulate the key transcriptional mediators of osteoblast differentiation, with ERK …
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