Mitogen-induced [Ca2+] i changes in individual human fibroblasts: Image analysis reveals asynchronous responses which are characteristic for different mitogens
KL Byron, ML Villereal - Journal of Biological Chemistry, 1989 - ASBMB
Temporal changes in intracellular free Ca 2+ concentration ([Ca 2+] i) in cultured human
foreskin fibroblasts were investigated using image analysis techniques to simultaneously
monitor Lys-bradykinin (BK)-or thrombin-induced elevations of [Ca 2+] i in each individual
cell within a microscopic field. Responses to BK are heterogeneous with respect to the
shapes of the [Ca 2+] i time courses. Furthermore, the onsets of these responses follow a
variable lag period such that the individual cell responses occur asynchronously. The …
foreskin fibroblasts were investigated using image analysis techniques to simultaneously
monitor Lys-bradykinin (BK)-or thrombin-induced elevations of [Ca 2+] i in each individual
cell within a microscopic field. Responses to BK are heterogeneous with respect to the
shapes of the [Ca 2+] i time courses. Furthermore, the onsets of these responses follow a
variable lag period such that the individual cell responses occur asynchronously. The …
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