Abstract Treatment paradigms for patients with upper tract urothelial carcinoma (UTUC) are
typically extrapolated from studies of bladder cancer despite their distinct clinical and
molecular characteristics. The advancement of UTUC research is hampered by the lack of
disease-specific models. Here, we report the establishment of patient derived xenograft
(PDX) and cell line models that reflect the genomic and biological heterogeneity of the
human disease. Models demonstrate high genomic concordance with the corresponding …

Re: Modeling Biological and Genetic Diversity in Upper Tract Urothelial Carcinoma with
Patient Derived Xenografts — Weizmann Research Portal … Re: Modeling Biological and
Genetic Diversity in Upper Tract Urothelial Carcinoma with Patient Derived Xenografts …