Modeling of C-terminal tail of human STING and its interaction with tank-binding kinase 1
RAO Al-Masri, H Audu-Bida… - Turkish Journal of …, 2022 - journals.tubitak.gov.tr
Stimulator of interferon genes (STING) plays a significant role in a cell's intracellular defense
against pathogens or self-DNA by inducing inflammation or apoptosis through a pathway
known as cGAS-cGAMP-STING. STING uses one of its domains, the C-terminal tail (CTT) to
recruit the members of the pathway. However, the structure of this domain has not been
solved experimentally. STING conformation is open and more flexible when inactive. When
STING gets activated by cGAMP, its conformation changes to a closed state covered by 4 …
against pathogens or self-DNA by inducing inflammation or apoptosis through a pathway
known as cGAS-cGAMP-STING. STING uses one of its domains, the C-terminal tail (CTT) to
recruit the members of the pathway. However, the structure of this domain has not been
solved experimentally. STING conformation is open and more flexible when inactive. When
STING gets activated by cGAMP, its conformation changes to a closed state covered by 4 …
Modelling of C-terminal tail of human STING and its interaction with tank-binding kinase 1.
R Ata Ouda Al-Masri, H Audu-Bida… - Turkish Journal of …, 2022 - search.ebscohost.com
Stimulator of interferon genes (STING) plays a significant role in a cell's intracellular defense
against pathogens or self-DNA by inducing inflammation or apoptosis through a pathway
known as cGAS-cGAMP-STING. STING uses one of its domains, the C-terminal tail (CTT) to
recruit the members of the pathway. However, the structure of this domain has not been
solved experimentally. STING conformation is open and more flexible when inactive. When
STING gets activated by cGAMP, its conformation changes to a closed state covered by 4 …
against pathogens or self-DNA by inducing inflammation or apoptosis through a pathway
known as cGAS-cGAMP-STING. STING uses one of its domains, the C-terminal tail (CTT) to
recruit the members of the pathway. However, the structure of this domain has not been
solved experimentally. STING conformation is open and more flexible when inactive. When
STING gets activated by cGAMP, its conformation changes to a closed state covered by 4 …
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