Modeling of waning immunity after SARS-CoV-2 vaccination and influencing factors
L Pérez-Alós, JJA Armenteros, JR Madsen… - Nature …, 2022 - nature.com
SARS-CoV-2 vaccines are crucial in controlling COVID-19, but knowledge of which factors
determine waning immunity is limited. We examined antibody levels and T-cell gamma-
interferon release after two doses of BNT162b2 vaccine or a combination of ChAdOx1-
nCoV19 and BNT162b2 vaccines for up to 230 days after the first dose. Generalized mixed
models with and without natural cubic splines were used to determine immunity over time.
Antibody responses were influenced by natural infection, sex, and age. IgA only became …
determine waning immunity is limited. We examined antibody levels and T-cell gamma-
interferon release after two doses of BNT162b2 vaccine or a combination of ChAdOx1-
nCoV19 and BNT162b2 vaccines for up to 230 days after the first dose. Generalized mixed
models with and without natural cubic splines were used to determine immunity over time.
Antibody responses were influenced by natural infection, sex, and age. IgA only became …
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