The rejection of disinfection byproducts (DBPs) is an important consideration for the application of forward osmosis (FO) in wastewater recycling. However, the transport of organic compounds in FO is not well predicted by existing models, partially because these models have not incorporated the effect of reverse salt flux, a phenomenon previously shown to influence the transport of pharmaceutical compounds. In this study, we investigated the effects of reverse salt flux on DBP transport in FO and the corresponding mechanisms. We used a commercial Aquaporin membrane and tested sixteen DBPs relevant to wastewater recycling. Using draw solutions constituted by NaCl, MgSO₄, or glucose in a bench-scale FO system, we first confirmed that higher reverse salt flux resulted in lower DBP permeance. By integrating results from the bench-scale FO system and those from diffusion cell tests, we showed that two mechanisms contributed to the hindered DBP transport: the steric hindrance in the active layer caused by the presence of the draw solute and the retarded diffusion of DBPs in the support layer via a “salting-out” effect. Lastly, we developed a modified solution-diffusion model incorporating these two mechanisms by accounting for the free volume occupied by draw solute molecules in the active layer and by introducing the Setschenow constant, respectively. The modified model significantly improved the prediction of permeance for halogenated DBPs, and revealed the relative importance of steric hindrance (dominant for large DBPs) and retarded diffusion (dominant for hydrophobic DBPs). The modified model did not accurately predict the permeance of nitrosamines, attributable to their extremely high hydrophilicity or large size.