and have been reported to exhibit an immunomodulatory activity by affecting the level of
cytokine production in vitro and in vivo. Due to the lack of adequate in vivo evidence in
dengue disease model, the present study was initiated to screen and identify the cytokines
affected by freeze-dried C. papaya leaf juice (FCPLJ) treatment in AG129 mice infected with
DEN-2 dengue virus. Methods The AG129 mice were fed orally with FCPLJ for 3 …