Molecular and spatial design of early skin development

T Jacob, K Annusver, P Czarnewski, T Dalessandri… - bioRxiv, 2022 - biorxiv.org
T Jacob, K Annusver, P Czarnewski, T Dalessandri, ME Kastriti, CL Levron, ML Mikkola
bioRxiv, 2022biorxiv.org
SUMMARY A wealth of specialized cell populations within the skin facilitates its hair
producing, protective, sensory and thermoregulatory functions, but how the vast cell-type
diversity and tissue architecture develops is largely unexplored. Here, with single-cell
transcriptomics, spatial cell-type assignment and cell-lineage tracing we deconstruct early
embryonic mouse skin during the key transitions from seemingly uniform developmental
precursor states to a multilayered, multilineage epithelium and complex dermal identity. We …
Summary
A wealth of specialized cell populations within the skin facilitates its hair producing, protective, sensory and thermoregulatory functions, but how the vast cell-type diversity and tissue architecture develops is largely unexplored. Here, with single-cell transcriptomics, spatial cell-type assignment and cell-lineage tracing we deconstruct early embryonic mouse skin during the key transitions from seemingly uniform developmental precursor states to a multilayered, multilineage epithelium and complex dermal identity. We reveal the spatiotemporal emergence of hair-follicle-inducing, muscle-supportive, and fascia-forming fibroblasts. We also uncover the formation of the panniculus carnosus muscle, sprouting blood vessels without pericyte coverage, and the earliest residence of mast and dendritic immune cells in skin. Finally, we reveal an unexpected epithelial heterogeneity within the early single-layered epidermis and a signaling-rich periderm layer. Overall, this cellular blueprint of early skin development establishes histological landmarks – essential for placing cells in their spatial tissue context – and highlights unprecedented dynamical interactions among skin cells.
biorxiv.org
以上显示的是最相近的搜索结果。 查看全部搜索结果