Molecular architecture of the major histocompatibility complex class I-binding site of Ly49 natural killer cell receptors
Natural killer (NK) cells play a vital role in the detection and destruction of virally infected
and tumor cells during innate immune responses. The highly polymorphic Ly49 family of NK
receptors regulates NK cell function by sensing major histocompatibility complex class I
(MHC-I) molecules on target cells. Despite the determination of two Ly49-MHC-I complex
structures, the molecular features of Ly49 receptors that confer specificity for particular MHC-
I alleles have not been identified. To understand the functional architecture of Ly49-binding …
and tumor cells during innate immune responses. The highly polymorphic Ly49 family of NK
receptors regulates NK cell function by sensing major histocompatibility complex class I
(MHC-I) molecules on target cells. Despite the determination of two Ly49-MHC-I complex
structures, the molecular features of Ly49 receptors that confer specificity for particular MHC-
I alleles have not been identified. To understand the functional architecture of Ly49-binding …
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