Dengue fever (DF) and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) are considered the most medically important and widespread mosquito-borne viral diseases. Dengueis an arbovirus that has a large occurrence in humans around the world. It is an infectious and debilitating disease caused by the dengue virus (DENV), by an arbovirus belonging to the family Flaviviridae and to the genus Flavivirus. The genome of this virus (DENV) encodes a long polyprotein, which is cleaved by viral and cellular proteases, giving rise to three structural proteins and seven non-structural proteins, among which is an NS1 protein, which is a highly protein Conserved, does not act in the stage of viral replication, being also linked to virulence and morphogenesis of the virus. Thus, knowing that NS1 is a protein that plays an important role without DENV virus, acting on the replication of its viral genome, it was sought to use it as a target molecule in molecular docking tests, to identify binding molecules that They can interact with this protein and may be potentially active against this virus. As the binding molecules are introduced two curcuminoids, Curcumin and Monodemethylcurcumin. By means of the donation between this target molecule and these binding points, it could be observed that for both couplings it has ten attractive twists between these molecules.(NS1), a bond between the H6 of the curcuminoid binder with a phenylalanine (PHE) 565 E chain of the protein, obtained the lowest value for a distance (3.5 Å). As for monodemethylcurcumin with the protein, the shortest distance obtained (3.8 Å) was observed at the binding of H15 of the ligand. Monodemethylcurcumin with the amino acid Glycine (GLY) 408 of the D chain of the protein. These ligands, therefore, are shown to be promising for Docking tests with a dengue virus (NS1) protein.