Molecular mechanisms for the destabilization of model membranes by islet amyloid polypeptide
MB Divakara, D Martinez, A Ravi, V Bhavana… - Biophysical …, 2019 - Elsevier
Misfolding of human islet amyloid polypeptide (hIAPP) into insoluble aggregates is
associated with Type 2 diabetes. It has been suggested that hIAPP toxicity may be due to its
accumulation in pancreatic islets, causing membrane disruption and cell permeabilization,
however the molecular basis underlying its lipid association are still unclear. Here, we
combine solid-state NMR, fluorescence and bright field microscopy to investigate hIAPP-
lipid membrane interactions. Real-time microscopy highlights a time-dependent penetration …
associated with Type 2 diabetes. It has been suggested that hIAPP toxicity may be due to its
accumulation in pancreatic islets, causing membrane disruption and cell permeabilization,
however the molecular basis underlying its lipid association are still unclear. Here, we
combine solid-state NMR, fluorescence and bright field microscopy to investigate hIAPP-
lipid membrane interactions. Real-time microscopy highlights a time-dependent penetration …
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