Molecular nanofibers of olsalazine form supramolecular hydrogels for reductive release of an anti-inflammatory agent
Journal of the American Chemical Society, 2010•ACS Publications
Conjugation of tripeptide derivatives with olsalazine, a clinically used anti-inflammatory
prodrug, yields small molecules that self-assemble in water to form supramolecular
hydrogels that undergo a gel-to-sol phase transition upon reduction, resulting in the
controlled release of 5-aminosalicylic acid as the anti-inflammatory agent. This methodology
will ultimately lead to new biomaterials for site-specific drug delivery.
prodrug, yields small molecules that self-assemble in water to form supramolecular
hydrogels that undergo a gel-to-sol phase transition upon reduction, resulting in the
controlled release of 5-aminosalicylic acid as the anti-inflammatory agent. This methodology
will ultimately lead to new biomaterials for site-specific drug delivery.
Conjugation of tripeptide derivatives with olsalazine, a clinically used anti-inflammatory prodrug, yields small molecules that self-assemble in water to form supramolecular hydrogels that undergo a gel-to-sol phase transition upon reduction, resulting in the controlled release of 5-aminosalicylic acid as the anti-inflammatory agent. This methodology will ultimately lead to new biomaterials for site-specific drug delivery.
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