The pathogenesis of hepatic fibrosis involves significant deposition of fibrilar collagen and
other extracellular matrix proteins. It is a rather dynamic process of wound healing in
response to a variety of persistent liver injury caused by factors such as ethanol intake, viral
infection, drugs, toxins, cholestasis, and metabolic disorders. Liver fibrosis distorts the
hepatic architecture, decreases the number of endothelial cell fenestrations and causes
portal hypertension. Key events are the activation and transformation of quiescent hepatic …