Monitoring phospholipids for assessment of ion enhancement and ion suppression in ESI and APCI LC/MS/MS for chlorpheniramine in human plasma and the …
OA Ismaiel, MS Halquist, MY Elmamly… - … of Chromatography B, 2008 - Elsevier
Biological matrix effects are a source of significant errors in both electrospray (ESI) and
atmospheric pressure chemical ionization (APCI) LC/MS. Glycerophosphocholines
(GPChos) and 2-lyso-glycerophosphocholines (2-lyso GPChos) are known to fragment to
form ions at m/z 184 and m/z 104, respectively. Phospholipids were used as markers to
evaluate matrix effects resulting in both ion suppression and enhancement using ESI and
APCI modes in the determination of chlorpheniramine in human plasma. Results revealed …
atmospheric pressure chemical ionization (APCI) LC/MS. Glycerophosphocholines
(GPChos) and 2-lyso-glycerophosphocholines (2-lyso GPChos) are known to fragment to
form ions at m/z 184 and m/z 104, respectively. Phospholipids were used as markers to
evaluate matrix effects resulting in both ion suppression and enhancement using ESI and
APCI modes in the determination of chlorpheniramine in human plasma. Results revealed …
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