Mono-2-ethylhexylphthalate (MEHP) induces TNF-α release and macrophage differentiation through different signalling pathways in RAW264. 7 cells
Epidemiological studies have associated indoor phthalate exposure with increased
incidences and severity of asthma in children and adults, and inflammatory effects have
been suggested as a possible mechanism. Recent studies report that phthalates may
activate mitogen-activated protein (MAP) kinase p38 and various peroxisome proliferator-
activated receptor (PPAR) isoforms. Here we confirm and extend these findings by
investigating possible signalling pathways activated in the murine monocyte-macrophage …
incidences and severity of asthma in children and adults, and inflammatory effects have
been suggested as a possible mechanism. Recent studies report that phthalates may
activate mitogen-activated protein (MAP) kinase p38 and various peroxisome proliferator-
activated receptor (PPAR) isoforms. Here we confirm and extend these findings by
investigating possible signalling pathways activated in the murine monocyte-macrophage …
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