Monoallelic expression and tissue specificity are associated with high crossover rates

A Necsulea, M Sémon, L Duret, LD Hurst - Trends in genetics, 2009 - cell.com
Trends in genetics, 2009cell.com
What determines the recombination rate of a gene? Following the observation that, in
humans, imprinted genes have unusually high recombination levels, we ask whether
increased recombination is seen for other monoallelically expressed genes and, more
generally, how transcriptional properties relate to recombination. We find that
monoallelically expressed genes do have high crossover rates and discover a striking
negative correlation between within-gene crossover rate and expression breadth. We …
What determines the recombination rate of a gene? Following the observation that, in humans, imprinted genes have unusually high recombination levels, we ask whether increased recombination is seen for other monoallelically expressed genes and, more generally, how transcriptional properties relate to recombination. We find that monoallelically expressed genes do have high crossover rates and discover a striking negative correlation between within-gene crossover rate and expression breadth. We hypothesise that these findings are possibly symptomatic of a more general, adverse relationship between recombination and transcription in the human genome.
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