Acute organophosphate pesticide poisoning is a common medical emergency with high
fatality in agricultural communities of Asia. Organophosphate compounds inhibit
acetylcholinesterase and prolonged neuromuscular weakness is a major cause of morbidity
and mortality of poisoning. Organophosphate pesticide induced muscle weakness may not
only arise from inhibition of acetylcholinesterase but also from non-cholinergic
pathomechanisms, particularly mitochondrial dysfunction, affecting the production of …