Monosomic loss of MIR15A/MIR16-1 is a driver of multiple myeloma proliferation and disease progression
The most common genetic abnormality in multiple myeloma is the deletion of chromosome
13, seen in almost half of newly diagnosed patients. Unlike chronic lymphocytic leukemia,
where a recurrent minimally deleted region including MIR15A/MIR16-1 has been mapped,
the deletions in multiple myeloma predominantly involve the entire chromosome and no
specific driver gene has been identified. Additional candidate loci include RB1 and DIS3, but
while biallelic deletion of RB1 is associated with disease progression, DIS3 is a common …
13, seen in almost half of newly diagnosed patients. Unlike chronic lymphocytic leukemia,
where a recurrent minimally deleted region including MIR15A/MIR16-1 has been mapped,
the deletions in multiple myeloma predominantly involve the entire chromosome and no
specific driver gene has been identified. Additional candidate loci include RB1 and DIS3, but
while biallelic deletion of RB1 is associated with disease progression, DIS3 is a common …
以上显示的是最相近的搜索结果。 查看全部搜索结果