Monozygotic twins discordant for severe clinical recurrence of COVID-19 show drastically distinct T cell responses to SARS-Cov-2
MV Castro, KS Santos, JS Apostolico, ER Fernandes… - medRxiv, 2021 - medrxiv.org
Background Clinical recurrence of COVID-19 in convalescent patients has been reported,
which immune mechanisms have not been thoroughly investigated. Presence of neutralizing
antibodies suggests other types of immune response are involved. Methods We assessed
the innate type I/III IFN response, T cell responses to SARS-CoV-2 with IFNγ ELISPOT,
binding and neutralizing antibody assays, in two monozygotic twin pairs with one COVID-19
recurrence case. Results In pair 1, four months after a first mild episode of infection for both …
which immune mechanisms have not been thoroughly investigated. Presence of neutralizing
antibodies suggests other types of immune response are involved. Methods We assessed
the innate type I/III IFN response, T cell responses to SARS-CoV-2 with IFNγ ELISPOT,
binding and neutralizing antibody assays, in two monozygotic twin pairs with one COVID-19
recurrence case. Results In pair 1, four months after a first mild episode of infection for both …
[HTML][HTML] Monozygotic twins discordant for severe clinical recurrence of COVID-19 show drastically distinct T cell responses to SARS-Cov-2
C MVd, KS Santos, JS Apostolico, ER Fernandes… - 2021 - europepmc.org
Background Clinical recurrence of COVID-19 in convalescent patients has been reported,
which immune mechanisms have not been thoroughly investigated. Presence of neutralizing
antibodies suggests other types of immune response are involved. Methods We assessed
the innate type I/III IFN response, T cell responses to SARS-CoV-2 with IFNγ ELISPOT,
binding and neutralizing antibody assays, in two monozygotic twin pairs with one COVID-19
recurrence case. Results In pair 1, four months after a first mild episode of infection for both …
which immune mechanisms have not been thoroughly investigated. Presence of neutralizing
antibodies suggests other types of immune response are involved. Methods We assessed
the innate type I/III IFN response, T cell responses to SARS-CoV-2 with IFNγ ELISPOT,
binding and neutralizing antibody assays, in two monozygotic twin pairs with one COVID-19
recurrence case. Results In pair 1, four months after a first mild episode of infection for both …
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