The distribution of radiopharmaceuticals in tumor cells represents a fundamental aspect for
a successful molecular targeted radiotherapy. It was largely demonstrated at microscopic
level that only a fraction of cells in tumoral tissues incorporate the radiolabel. In addition, the
distribution of the radionuclides at sub-cellular level, namely inside each nucleus, should
also be investigated for accurate dosimetry estimation. The most used method to perform
cellular dosimetry is the MIRD one, where S-values are able to estimate cellular absorbed …