Morphine withdrawal enhances HIV infection of macrophages

X Wang, J Liu, L Zhou, WZ Ho - Frontiers in immunology, 2019 - frontiersin.org
… (AW) and precipitated withdrawal (PW). In this study, we examined the effect of morphine
AW or morphine PW on HIV infection of human blood monocyte-derived macrophages. We …

An in vitro model of morphine withdrawal manifests the enhancing effect on human immunodeficiency virus infection of human T lymphocytes through the induction of …

X Wang, SD Douglas, JS Peng, DJ Zhou, Q Wan… - The American journal of …, 2006 - Elsevier
… of macrophages and microglia… morphine withdrawal on HIV infection of human T lymphocytes.
We also investigated the role of SP in morphine withdrawal-mediated enhancement of HIV

Morphine enhances HIV infection of human blood mononuclear phagocytes through modulation of β-chemokines and CCR5 receptor

CJ Guo, Y Li, S Tian, X Wang… - Journal of …, 2002 - journals.sagepub.com
… To examine the hypothesis that morphine enhances HIV infection of MDM by affecting
viral entry, we examined the effect of morphine on ADA (CCR5-dependent and macrophage-tropic…

Morphine withdrawal dramatically reduces lymphocytes in morphine-dependent macaques

MR Weed, LM Carruth, RJ Adams, NA Ator… - Journal of Neuroimmune …, 2006 - Springer
… The major finding in this study is the demonstration that the morphine withdrawal syndrome
included both an increase in absolute numbers of neutrophils and a dramatic reduction in …

CCR5 mediates HIV-1 Tat-induced neuroinflammation and influences morphine tolerance, dependence, and reward

M Gonek, VD McLane, DL Stevens, K Lippold… - Brain, behavior, and …, 2018 - Elsevier
… Tat decreases morphine withdrawal and CCR5 antagonism … the HIV and opioid epidemics
is particularly concerning given evidence that opioid usage increases the progression of HIV-…

The role of opioid receptors in immune system function

TK Eisenstein - Frontiers in immunology, 2019 - frontiersin.org
Morphine and morphine withdrawal have been shown to … heroin enhanced HIV replication
in human macrophages in … , and miRNA-382) that restrict HIV replication (67). Long et al. …

Effect of opioid use on immune activation and HIV persistence on ART

L Azzoni, D Metzger, LJ Montaner - Journal of Neuroimmune …, 2020 - Springer
… While both lymphocytes and monocyte/macrophages express functional MOR, the effects of
… 2008b) In myeloid cells, morphine enhances HIV infection and replication in macrophages

Effects of opioid tolerance and withdrawal on the immune system

TK Eisenstein, RT Rahim, P Feng… - Journal of Neuroimmune …, 2006 - Springer
… cells from placebo withdrawn or morphine withdrawn mice with … that withdrawal from
morphine results in macrophages that … To assess whether morphine enhanced sensitivity to this …

Methadone inhibits viral restriction factors and facilitates HIV infection in macrophages

MR Wang, DD Wu, F Luo, CJ Zhong, X Wang… - Frontiers in …, 2020 - frontiersin.org
… used opioid receptor agonist for treatment of opiate addiction… craving for opioids, prevents
opioid withdrawal symptoms, and blocks … In our finding, methadone may enhance HIV infection

Opioid drug abuse and modulation of immune function: consequences in the susceptibility to opportunistic infections

S Roy, J Ninkovic, S Banerjee, RG Charboneau… - Journal of Neuroimmune …, 2011 - Springer
… indicated chronic opioid treatment is opioid withdrawal. Data … of subsequent macrophage
chemotaxis by morphine occurs … caused an increase in apoptosis following morphine treatment…