Multi-component reactions and evolutionary chemistry
L Weber - Drug discovery today, 2002 - Elsevier
Drug discovery today, 2002•Elsevier
Multi-component reactions (MCRs) provide a new approach towards the efficient synthesis
of diverse compounds and compound libraries. MCRs are evolving from being purely a
chemistry curiosity to being recognized as having increasing relevance for drug discovery in
terms of lead discovery and optimization. The combination of MCR-type chemistry-planning
with evolutionary in silico and in vitro prediction of drug potential or biological properties is a
new and powerful tool in drug discovery.
of diverse compounds and compound libraries. MCRs are evolving from being purely a
chemistry curiosity to being recognized as having increasing relevance for drug discovery in
terms of lead discovery and optimization. The combination of MCR-type chemistry-planning
with evolutionary in silico and in vitro prediction of drug potential or biological properties is a
new and powerful tool in drug discovery.
Multi-component reactions (MCRs) provide a new approach towards the efficient synthesis of diverse compounds and compound libraries. MCRs are evolving from being purely a chemistry curiosity to being recognized as having increasing relevance for drug discovery in terms of lead discovery and optimization. The combination of MCR-type chemistry-planning with evolutionary in silico and in vitro prediction of drug potential or biological properties is a new and powerful tool in drug discovery.
Elsevier
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