Rapidly intensifying necessitates of energy and depletion of accessible fossil resources has made a remarkable interest in investigation of the alternative fuels. The current investigational work was performed to examine the use of multi-objective optimization (MOP) based on response surface methodology (RSM) to investigate the impact of compression ratio (CR), biogas flow rate and engine load on the performance of dual-fuel engine. An engine load of 80%, compression ratio of 18, and biogas flow rate of 2.8 kg/h were observed to be optimal condition. According to these optimized parameters, the value of BTE, NO_X, UHC, CO and smoke opacity were found to be 18.51(%), 13.5 (g/kW.hr), 0.49 (g/kW.hr), CO (0.08% vol.) and 23.6 (%), respectively. Compared with conventional diesel fuel, dual-fuel operational mode can improve brake specific energy consumption and reduce NO_X as well as Smoke opacity, while producing higher emissions of CO and UHC.