Multidimensional coculture system to model lung squamous carcinoma progression
S Chen, A Giannakou, J Golas, KG Geles - JoVE (Journal of Visualized …, 2020 - jove.com
Tumor-stroma interactions play a critical role in the development of lung squamous
carcinoma (LUSC). However, understanding how these dynamic interactions contribute to
tissue architectural changes observed during tumorigenesis remains challenging due to the
lack of appropriate models. In this protocol, we describe the generation of a 3D coculture
model using a LUSC primary cell culture known as TUM622. TUM622 cells were
established from a LUSC patient-derived xenograft (PDX) and have the unique property to …
carcinoma (LUSC). However, understanding how these dynamic interactions contribute to
tissue architectural changes observed during tumorigenesis remains challenging due to the
lack of appropriate models. In this protocol, we describe the generation of a 3D coculture
model using a LUSC primary cell culture known as TUM622. TUM622 cells were
established from a LUSC patient-derived xenograft (PDX) and have the unique property to …
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