Multimodal multiplexed immunoimaging with nanostars to detect multiple immunomarkers and monitor response to immunotherapies
The overexpression of immunomarker programmed cell death protein 1 (PD-1) and
engagement of PD-1 to its ligand, PD-L1, are involved in the functional impairment of cluster
of differentiation 8+(CD8+) T cells, contributing to cancer progression. However,
heterogeneities in PD-L1 expression and variabilities in biopsy-based assays render current
approaches inaccurate in predicting PD-L1 status. Therefore, PD-L1 screening alone is not
predictive of patient response to treatment, which motivates us to simultaneously detect …
engagement of PD-1 to its ligand, PD-L1, are involved in the functional impairment of cluster
of differentiation 8+(CD8+) T cells, contributing to cancer progression. However,
heterogeneities in PD-L1 expression and variabilities in biopsy-based assays render current
approaches inaccurate in predicting PD-L1 status. Therefore, PD-L1 screening alone is not
predictive of patient response to treatment, which motivates us to simultaneously detect …
[PDF][PDF] Multimodal Multiplexed Immunoimaging with Nanostars to Detect Multiple Immunomarkers and Monitor Response to Immunotherapies.
The overexpression of immunomarker programmed cell death protein 1 (PD-1) and
engagement of PD-1 to its ligand, PD-L1, are involved in the functional impairment of cluster
of differentiation 8+(CD8+) T cells, contributing to cancer progression. However,
heterogeneities in PD-L1 expression and variabilities in biopsy-based assays render current
approaches inaccurate in predicting PD-L1 status. Therefore, PD-L1 screening alone is not
predictive of patient response to treatment, which motivates us to simultaneously detect …
engagement of PD-1 to its ligand, PD-L1, are involved in the functional impairment of cluster
of differentiation 8+(CD8+) T cells, contributing to cancer progression. However,
heterogeneities in PD-L1 expression and variabilities in biopsy-based assays render current
approaches inaccurate in predicting PD-L1 status. Therefore, PD-L1 screening alone is not
predictive of patient response to treatment, which motivates us to simultaneously detect …
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