We present techniques for inertial-sensing atom interferometers which produce multiple phase measurements per experimental cycle. With these techniques, we realize two types of multiport measurements, namely, quadrature phase detection and real-time systematic phase cancellation, which address challenges in operating high-sensitivity cold-atom sensors in mobile and field applications. We confirm experimentally the increase in sensitivity due to quadrature phase detection in the presence of large phase uncertainty, and demonstrate suppression of systematic phases on a single-shot basis.